We’re ready now, Marks says, and we don’t really have a choice.. “Technology has changed, the environment has changed, the workforce has changed, the designs are more complex.

The perceived immaturity of the state-of-the-art.There is a belief that the technology involved in intensified chemistry is not very mature and therefore carries substantial risk.

Some of the small-scale hardware has not been fully industrialised, the developing data collection, process and quality control approaches have not been fully tested with regulatory authorities..Complicated supply chain.Pharmaceutical manufacturing of a single product through its lifecycle spans multiple functions and sites within each organisation and spans multiple organisations through product acquisitions and contract manufacturing.

Thus, the breadth of what needs to be changed to deploy a new platform technology is significant.. Resistance to challenging accepted practice.Regulatory and patient safety risks are always high up the agenda for the pharmaceutical industry.

The unfamiliar and the new are assessed as having higher risk than the known.. How manufacturing sits versus perceived value creation in the pharmaceutical companies.

In reality, pharmaceutical value creation comes from the development or acquisition of promising NCEs, and their ability to commercialise them.The manufactured brackets that create the interfaces between beams and columns use very simple standardise tasks (bolted together vs requiring specialist steel erectors) ensuring a level of consistency normally unachievable in traditional construction..

Brackets are designed in a way that they can only be installed correctly (referred to as ‘poka-yoke’ in manufacturing) making it impossible for an error to occur or making the error immediately obvious.In addition, the brackets are colour coded, with each colour relating to a specific condition, e.g.

end of bay, base of column etc.Each colour is also liked to a series of standard tasks, such as a number of bolts and setting on their torque wrench.